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类风湿关节炎患者停用甲氨蝶呤后低度B细胞非霍奇金淋巴瘤自发缓解:病例报告及文献复习

Spontaneous remission of low-grade B-cell non-Hodgkin's lymphoma following withdrawal of methotrexate in a patient with rheumatoid arthritis: case report and review of the literature.

作者信息

Baird Richard D, van Zyl-Smit Richard Nellis, Dilke Timothy, Scott Sara E, Rassam Saad M B

机构信息

Department of Haematology and Department of Rheumatology, Queen Mary's Hospital, Sidcup, Kent DA14 6LR, UK.

出版信息

Br J Haematol. 2002 Aug;118(2):567-8. doi: 10.1046/j.1365-2141.2002.03619.x.

DOI:10.1046/j.1365-2141.2002.03619.x
PMID:12139747
Abstract

A 69-year-old woman, who had suffered from deforming rheumatoid arthritis since the age of 40 years, had been treated with methotrexate for 3 years. She presented with a 7 week history of neck lymphadenopathy. Biopsy revealed low-grade marginal-zone B-cell non-Hodgkin's lymphoma. Computerized tomography and bone marrow biopsy confirmed stage IIIA disease. Spontaneous complete remission of the lymphoma was achieved 14 months after withdrawing immune suppression with methotrexate.

摘要

一名69岁女性,自40岁起患有变形性类风湿关节炎,已接受甲氨蝶呤治疗3年。她出现颈部淋巴结病7周病史。活检显示为低度边缘区B细胞非霍奇金淋巴瘤。计算机断层扫描和骨髓活检证实为IIIA期疾病。停用甲氨蝶呤免疫抑制14个月后,淋巴瘤实现自发完全缓解。

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