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范可尼贫血患者培养细胞的生长情况。

Growth of cultured cells from patients with Fanconi anemia.

作者信息

Elmore E, Swift M

出版信息

J Cell Physiol. 1975 Dec;87(2):229-33. doi: 10.1002/jcp.1040870211.

DOI:10.1002/jcp.1040870211
PMID:1214005
Abstract

Fibroblast cultures derived from skin biopsies of patients with Fanconi anemia had doubling times (mean of five lines: 30.3 +/- 0.2 hours) significantly longer than randomly selected normal controls (mean of nine lines: 22.9 +/- 0.4 hours). Control cultures grew more slowly in the enriched media RPMI 1640 and McCoy's 5A than in MEM; while a culture from a patient with Fanconi anemia grew more slowly only in McCoy's 5A. Differences in growth characteristics between Fanconi anemia and normal cell cultures may be useful in analyzing the metabolic error determined by the Fanconi anemia gene.

摘要

来自范可尼贫血患者皮肤活检的成纤维细胞培养物的倍增时间（五条细胞系的平均值：30.3±0.2小时）显著长于随机选择的正常对照（九条细胞系的平均值：22.9±0.4小时）。对照培养物在富集培养基RPMI 1640和 McCoy's 5A中比在MEM中生长得更慢；而来自范可尼贫血患者的一种培养物仅在McCoy's 5A中生长得更慢。范可尼贫血细胞培养物与正常细胞培养物生长特性的差异可能有助于分析由范可尼贫血基因决定的代谢错误。

相似文献

1
Growth of cultured cells from patients with Fanconi anemia.范可尼贫血患者培养细胞的生长情况。
J Cell Physiol. 1975 Dec;87(2):229-33. doi: 10.1002/jcp.1040870211.
2
Specific cellular defects in patients with Fanconi anemia.范可尼贫血患者的特定细胞缺陷。
J Cell Physiol. 1979 Nov;101(2):311-23. doi: 10.1002/jcp.1041010211.
3
The effect of dexamethasone on the growth of bone marrow fibroblasts in aplastic anemia.地塞米松对再生障碍性贫血患者骨髓成纤维细胞生长的影响。
Prog Clin Biol Res. 1984;154:265-74.
4
[In vitro proliferation and differentiation of bone marrow stem cells of aplastic anemia patients].[再生障碍性贫血患者骨髓干细胞的体外增殖与分化]
Zhonghua Xue Ye Xue Za Zhi. 1999 Oct;20(10):529-31.
5
The membrane-bound isoform of stem cell factor synergizes with soluble flt3 ligand in supporting early hematopoietic cells in long-term cultures of normal and aplastic anemia bone marrow.干细胞因子的膜结合异构体与可溶性fms样酪氨酸激酶3配体协同作用，在正常和再生障碍性贫血骨髓的长期培养中支持早期造血细胞。
Exp Hematol. 1998 May;26(5):365-73.
6
Fibroblasts from patients with Fanconi's anemia are not deficient in excision of thymine dimer.范科尼贫血患者的成纤维细胞在切除胸腺嘧啶二聚体方面并不缺乏。
Eur J Cell Biol. 1985 May;37:240-2.
7
Fanconi anemia with primary pneumococcal peritonitis--a case report.范可尼贫血合并原发性肺炎球菌性腹膜炎——病例报告
Indian Pediatr. 1980 Feb;17(2):185-9.
8
Reassessment of cancer predisposition of Fanconi anemia heterozygotes.范可尼贫血杂合子癌症易感性的重新评估。
J Natl Cancer Inst. 1980 Nov;65(5):863-7.
9
Mitomycin C test for diagnostic differentiation of idiopathic aplastic anemia and Fanconi anemia.丝裂霉素C试验用于特发性再生障碍性贫血和范科尼贫血的诊断鉴别
Pediatrics. 1981 Jan;67(1):119-27.
10
Deoxyribonucleoside triphosphate pool levels in three cell strains of human chromosome instability syndromes: ataxia telangiectasia (GM2052), Bloom's syndrome (GM1492), and Fanconi's anemia (GM368).三种人类染色体不稳定综合征细胞株中的脱氧核糖核苷三磷酸池水平：共济失调毛细血管扩张症（GM2052）、布卢姆综合征（GM1492）和范科尼贫血（GM368）。
Cancer Biochem Biophys. 1990 Jan;11(1):69-77.

引用本文的文献

1
Elevated levels of somatic mutation in a manifesting BRCA1 mutation carrier.一名有临床表现的BRCA1突变携带者的体细胞突变水平升高。
Pathol Oncol Res. 2007;13(4):276-83. doi: 10.1007/BF02940305. Epub 2007 Dec 25.
2
Reduced uptake and incorporation of 3H-thymidine in Fanconi anemia fibroblasts.范可尼贫血成纤维细胞中³H-胸腺嘧啶核苷摄取和掺入减少。
Hum Genet. 1981;57(3):296-9. doi: 10.1007/BF00278948.
3
Proliferative kinetics and mitomycin C-induced chromosome damage in Fanconi's anemia lymphocytes.范科尼贫血淋巴细胞的增殖动力学及丝裂霉素C诱导的染色体损伤
Hum Genet. 1983;63(1):19-23. doi: 10.1007/BF00285391.
4
Fanconi's anemia: anomaly of enzyme passage through the nuclear membrane? Anomalous intracellular distribution of topoisomerase activity in placental extracts in a case of Fanconi's anemia.范科尼贫血：酶通过核膜的异常现象？一例范科尼贫血病例中胎盘提取物拓扑异构酶活性的细胞内异常分布。
Hum Genet. 1981;58(2):149-55. doi: 10.1007/BF00278700.
5
DNA semi-conservative synthesis in normal and Fanconi anemia fibroblasts following treatment with 8-methoxypsoralen and near ultraviolet light or with X-rays.用8-甲氧基补骨脂素和近紫外线或X射线处理后，正常和范科尼贫血成纤维细胞中的DNA半保留合成
Hum Genet. 1985;70(3):236-42. doi: 10.1007/BF00273448.
6
Two complementation groups of Fanconi's anemia differ in their phenotypic response to a DNA-crosslinking treatment.范科尼贫血的两个互补组对DNA交联处理的表型反应有所不同。
Hum Genet. 1987 Jan;75(1):45-7. doi: 10.1007/BF00273837.
7
Fanconi anemia mutation causes cellular susceptibility to ambient oxygen.范可尼贫血突变导致细胞对环境氧的易感性。
Am J Hum Genet. 1988 Oct;43(4):429-35.
8
Abnormal response to DNA crosslinking agents of Fanconi anemia fibroblasts can be corrected by transfection with normal human DNA.范可尼贫血成纤维细胞对DNA交联剂的异常反应可通过用正常人DNA转染来纠正。
Proc Natl Acad Sci U S A. 1986 Sep;83(18):7034-8. doi: 10.1073/pnas.83.18.7034.
9
Partial complementation of the Fanconi anemia defect upon transfection by heterologous DNA. Phenotypic dissociation of chromosomal and cellular hypersensitivity to DNA cross-linking agents.通过异源DNA转染对范可尼贫血缺陷进行部分互补。染色体和细胞对DNA交联剂超敏反应的表型解离。
Hum Genet. 1990 Dec;86(2):151-61. doi: 10.1007/BF00197697.
10
Growth of human skin fibroblasts in dialyzed fetal bovine serum.人皮肤成纤维细胞在透析胎牛血清中的生长
In Vitro. 1977;13(12):837-42. doi: 10.1007/BF02615132.