来自马达加斯加雨林的斑点奥克罗卡波斯树皮中的新型细胞毒性香豆素和异戊烯基化二苯甲酮衍生物。

New cytotoxic coumarins and prenylated benzophenone derivatives from the bark of Ochrocarpos punctatus from the Madagascar rainforest.

作者信息

Chaturvedula V S Prakash, Schilling Jennifer K, Kingston David G I

机构信息

Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA.

出版信息

J Nat Prod. 2002 Jul;65(7):965-72. doi: 10.1021/np020030a.

DOI:10.1021/np020030a

PMID:12141854

Abstract

Bioassay-guided fractionation of a CH2Cl2-MeOH extract of the bark of Ochrocarpos punctatus resulted in the isolation of seven new coumarins, ochrocarpins A-G (1-7), three new benzophenone derivatives, ochrocarpinones A-C (8-10), and five known coumarins, mammea A/AC cyclo F (11), mammea A/AD cyclo D (12), mammea A/AB cyclo F (13), mammea A/AA cyclo F (14), mammea A/AB cyclo D (15), and 15,16-dihydro-16-hydroperoxyplukenetione (16). The structures of compounds 1-10 were established on the basis of extensive 1D and 2D NMR spectroscopic data interpretation. All compounds exhibited cytotoxicity against the A2780 ovarian cancer cell line.

摘要

对斑点红厚壳树皮的二氯甲烷 - 甲醇提取物进行生物测定导向的分级分离，得到了七种新的香豆素，即斑点红厚壳素A - G（1 - 7），三种新的二苯甲酮衍生物，即斑点红厚壳酮A - C（8 - 10），以及五种已知的香豆素，即莫米A/AC环F（11）、莫米A/AD环D（12）、莫米A/AB环F（13）、莫米A/AA环F（14）、莫米A/AB环D（15）和15,16 - 二氢 - 16 - 氢过氧化普卢开内酮（16）。化合物1 - 10的结构是基于广泛的一维和二维核磁共振光谱数据解释确定的。所有化合物对A2780卵巢癌细胞系均表现出细胞毒性。