藤黄双黄酮K和L，来自马达加斯加雨林的钙生巴西藤黄的抗增殖化合物。
Guttiferones K and L, antiproliferative compounds of Rheedia calcicola from the Madagascar rain forest.
作者信息
Cao Shugeng, Brodie Peggy J, Miller James S, Ratovoson Fidy, Birkinshaw Chris, Randrianasolo Sennen, Rakotobe Etienne, Rasamison Vincent E, Kingston David G I
机构信息
Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA.
出版信息
J Nat Prod. 2007 Apr;70(4):686-8. doi: 10.1021/np070004i. Epub 2007 Mar 10.
Abstract
Bioassay-guided fractionation of the ethanol extract obtained from the fruits of Rheedia calcicola led to the isolation of two new guttiferone analogues, guttiferones K (1) and L (16-hydroxyguttiferone K) (2). The structures of 1 and 2 were established on the basis of extensive interpretation of one- and two-dimensional NMR spectroscopic data. Both compounds were tested for their antiproliferative activity against the A2780 human ovarian cancer cell line.
摘要
对从钙生巴西瑞香果实中获得的乙醇提取物进行生物测定引导的分级分离，得到了两种新的呫吨酮类似物，呫吨酮K（1）和L（16-羟基呫吨酮K）（2）。根据对一维和二维核磁共振光谱数据的广泛解读确定了1和2的结构。对这两种化合物针对A2780人卵巢癌细胞系的抗增殖活性进行了测试。
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2
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