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Biologically active alkylated coumarins from Kayea assamica.

作者信息

Lee Kyung-Hee, Chai Hee-Byung, Tamez Pamela A, Pezzuto John M, Cordell Geoffrey A, Win Khin Khin, Tin-Wa Maung

机构信息

Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.

出版信息

Phytochemistry. 2003 Sep;64(2):535-41. doi: 10.1016/s0031-9422(03)00243-7.

Abstract

Four coumarin derivatives, theraphins A (1), B (2), C (3), and D (4), along with three known xanthones, 2-hydroxyxanthone, 1,7-dihydroxyxanthone, and 5-hydroxy-1-methoxyxanthone, were isolated from the bark of Kayea assamica (Clusiaceae) native to Myanmar. Their structures were determined using spectroscopic and chemical techniques. The absolute configuration of 1 was established by the modified Mosher ester method. Theraphins A (1), B (2), and C (3) exhibited good cytotoxicity against Col2, KB, and LNCaP human cancer cell lines. Theraphin D (4) showed mild activity only against the KB cell line. The coumarins also exhibited mild antimalarial activities.

摘要

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