从金钱松中分离得到的五种新二萜类化合物。

Five new diterpenoids from Pseudolarix kaempferi.

作者信息

Yang Sheng-Ping, Wu Yan, Yue Jian-Min

机构信息

Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai, 200031, People's Republic of China.

出版信息

J Nat Prod. 2002 Jul;65(7):1041-4. doi: 10.1021/np0200010.

DOI:10.1021/np0200010

PMID:12141871

Abstract

Five new diterpenoids, pseudolaric acids F (1), G (2), and H (3), 2',3'-dihydroxy-1'-propoxypseudolarate B (4), and 6'-O-acetylpseudolaric acid B O-beta-D-glucopyranoside (5), along with nine known diterpenoids, pseudolaric acids A, B, and C(1), deacetylpseudolaric acid C(2), deacetylpseudolaric acid A, methyl pseudolarate A, methyl pseudolarate B, pseudolaric acid A-O-beta-D-glucopyranoside, and pseudolaric acid B-O-beta-D-glucopyranoside, were isolated from the root bark of Pseudolarix kaempferi. Their structures and stereochemistry were elucidated mainly by spectral data, especially 2D NMR techniques.

摘要

从金钱松的根皮中分离出5个新的二萜类化合物，即土槿皮酸F（1）、G（2）和H（3）、2'，3'-二羟基-1'-丙氧基土槿皮酸盐B（4）以及6'-O-乙酰基土槿皮酸B O-β-D-吡喃葡萄糖苷（5），同时还分离出9个已知的二萜类化合物，即土槿皮酸A、B和C（1）、去乙酰基土槿皮酸C（2）、去乙酰基土槿皮酸A、甲基土槿皮酸盐A、甲基土槿皮酸盐B、土槿皮酸A-O-β-D-吡喃葡萄糖苷和土槿皮酸B-O-β-D-吡喃葡萄糖苷。它们的结构和立体化学主要通过光谱数据，尤其是二维核磁共振技术得以阐明。