金钱松树皮中的细胞毒性二萜类化合物及其构效关系

Cytotoxic diterpenoids from the bark of Pseudolarix kaempferi and their structure-activity relationships.

作者信息

Liu Peng, Guo Hongzhu, Wang Weixing, Zhang Jie, Li Na, Han Jian, Zhou Jianping, Hu Yuchi, Zhang Tong, Liu Zhenming, Guo Dean

机构信息

Division of Pharmacognostical Biotechnology, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100083, People's Republic of China.

出版信息

J Nat Prod. 2007 Apr;70(4):533-7. doi: 10.1021/np060439q. Epub 2007 Feb 10.

DOI:10.1021/np060439q

PMID:17291040

Abstract

Four new diterpenoids, 11S-deacetylpseudolaric acid A (2), deacetylpseudolaric acid A O-beta-d-glucopyranoside (3), deacetylpseudolaric acid A 2,3-dihydroxypropyl ester (4), and deacetylpseudolaric acid B 2,3-dihydroxypropyl ester (5), and nine known diterpenoids were isolated from the bark of Pseudolarix kaempferi. Their structures were determined on the basis of chemical and spectroscopic analyses. In addition, their in vitro cytotoxic activities against three human cancer cell lines and their structure-activity relationships were evaluated.

摘要

从金钱松的树皮中分离出4个新的二萜类化合物，11S-去乙酰基伪海松酸A（2）、去乙酰基伪海松酸A O-β-D-吡喃葡萄糖苷（3）、去乙酰基伪海松酸A 2,3-二羟基丙酯（4）和去乙酰基伪海松酸B 2,3-二羟基丙酯（5），以及9个已知的二萜类化合物。通过化学和光谱分析确定了它们的结构。此外，还评估了它们对三种人类癌细胞系的体外细胞毒性活性及其构效关系。