肾转移性横纹肌样瘤的治疗。
Treatment of metastatic rhabdoid tumor of the kidney.
作者信息
Wagner Lars, Hill D Ashley, Fuller Christine, Pedrosa Márcia, Bhakta Manoo, Perry Arie, Dome Jeffrey S
机构信息
Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA.
出版信息
J Pediatr Hematol Oncol. 2002 Jun-Jul;24(5):385-8. doi: 10.1097/00043426-200206000-00012.
Metastatic rhabdoid tumor of the kidney (RTK) is a highly lethal malignancy; only one survivor with stage 4 disease has been reported. The authors reviewed the cases of two patients with metastatic RTK who had excellent responses to therapy. Both patients were treated with radiation therapy and alternating courses of ifosfamide, carboplatin, and etoposide (ICE) and vincristine, doxorubicin, and cyclophosphamide (VDC). The patients are without evidence of disease at 24 months and 12 months from the detection of metastasis. Alternating courses of ICE and VDC have activity against metastatic RTK. This combination of agents warrants prospective investigation in clinical trials.
肾转移性横纹肌样瘤（RTK）是一种高度致命的恶性肿瘤；据报道，仅有一名IV期疾病患者存活。作者回顾了两例转移性RTK患者的病例，这两名患者对治疗均有良好反应。两名患者均接受了放射治疗，并交替使用异环磷酰胺、卡铂和依托泊苷（ICE）以及长春新碱、多柔比星和环磷酰胺（VDC）进行治疗。自发现转移起，两名患者分别在24个月和12个月时均无疾病证据。ICE和VDC交替疗程对转移性RTK有活性。这种联合用药方案值得在临床试验中进行前瞻性研究。
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