Alavi Samin, Rashidi Armin, Khatami Ali Reza, Arzanian Mohammad Taghi
Department of Pediatric Hematology and Oncology, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
Pediatr Hematol Oncol. 2007 Mar;24(2):123-8. doi: 10.1080/08880010601069963.
Rhabdoid tumor of the kidney (RTK) is a rare and highly malignant neoplasm of infancy, with a strong tendency for early metastasis to distant regions. RTK is unique in its significant association with primary or metastatic brain tumors. The authors report the first case of RTK presenting initially with hemiplegia. The patient was found thereafter to have RTK concurrent with pulmonary metastases, a brain tumor, and a cerebral ischemic lesion. Intensive chemotherapy consisting of carboplatin and etoposide alternating with cyclophosphamide was unsuccessful and the patient died 5 months later because of severe respiratory distress resulting from widespread pulmonary metastases.
肾横纹肌样瘤(RTK)是一种罕见的婴儿期高度恶性肿瘤,具有早期远处转移的强烈倾向。RTK的独特之处在于它与原发性或转移性脑肿瘤有显著关联。作者报告了首例最初表现为偏瘫的RTK病例。此后发现该患者同时患有RTK、肺转移瘤、脑肿瘤和脑缺血性病变。由卡铂和依托泊苷交替联合环磷酰胺组成的强化化疗未成功,患者5个月后因广泛肺转移导致的严重呼吸窘迫而死亡。