采用ICE和VDCy方案治疗IV期肾恶性横纹肌样瘤（MRTK）：1例病例报告

Treatment of stage IV malignant rhabdoid tumor of the kidney (MRTK) with ICE and VDCy: a case report.

作者信息

Yamamoto Masaki, Suzuki Nobuhiro, Hatakeyama Naoki, Mizue Nobuo, Hori Tsukasa, Kuroiwa Yuki, Hareyama Masato, Oda Takanori, Kudoh Tooru, Nui Akihiro, Matsuno Takashi, Hirama Toshinori, Yokoyama Shigeaki, Dome Jeffrey S, Tsutsumi Hiroyuki

机构信息

Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan.

出版信息

J Pediatr Hematol Oncol. 2006 May;28(5):286-9. doi: 10.1097/01.mph.0000212901.84146.5a.

DOI:10.1097/01.mph.0000212901.84146.5a

PMID:16772877

Abstract

The prognosis of stage IV malignant rhabdoid tumor of the kidney (MRTK) has been extremely poor. However, a combination of ICE (ifosfamide, carboplatin, and etoposide) and VDCy (vincristine, doxorubicin, and cyclophosphamide) was recently reported to be effective for metastatic MRTK. We describe a 21-month-old girl with stage IV MRTK who was successfully treated with ICE, VDCy, and radiotherapy. She remained well, without recurrence, 24 months after diagnosis. Alternating therapy with ICE and VDCy might become a standard regimen for stage IV MRTK, although further study is required to confirm its effectiveness.

摘要

IV期肾恶性横纹肌样瘤（MRTK）的预后一直极差。然而，最近有报道称，异环磷酰胺、卡铂和依托泊苷（ICE）联合长春新碱、多柔比星和环磷酰胺（VDCy）对转移性MRTK有效。我们报告了一名21个月大的IV期MRTK女童，她接受ICE、VDCy和放疗后成功治愈。诊断后24个月，她情况良好，未复发。ICE和VDCy交替治疗可能会成为IV期MRTK的标准治疗方案，不过还需要进一步研究以证实其有效性。