长叶海利埃塔树的喹啉生物碱、香豆素和挥发性成分。

Quinoline alkaloids, coumarins and volatile constituents of Helietta longifoliata.

作者信息

de Moura Neusa F, Simionatto Euclésio, Porto Carla, Hoelzel Solange C, Dessoy Emilia C, Zanatta Nilo, Morel Ademir F

机构信息

Departamento de Química, Universidade Federal de Santa Maria, RS, Brazil.

出版信息

Planta Med. 2002 Jul;68(7):631-4. doi: 10.1055/s-2002-32898.

DOI:10.1055/s-2002-32898

PMID:12142998

Abstract

A new quinoline alkaloid named helietidine ( 1), and seven known compounds ( 2 - 8) have been isolated from the stem barks of Helietta longifoliata. The structures of the new and the known compounds were established on the basis of spectral evidence, especially by 2D NMR ( 1H- 1H COSY, NOESY, HMQC, HMBC). In addition, the volatile constituents of H. longifoliata leaves were analysed by gas chromatography-mass spectrometry (GC-MS). Twenty-five constituents were identified representing ca. of 96 % of the oil, and limonene (17.50 %), germacrene D (16.60 %), elemol (11.81 %), bicyclogermacrene (11.67 %), guaiol (11.53), and epi-alpha-bisabolol (7.24 %) were the most abundant components. The oil was bioactive against some Gram-positive and Gram-negative bacteria, as revealed by bioautography.

摘要

从长叶海榄雌的茎皮中分离出一种名为海榄雌定碱（1）的新喹啉生物碱以及七种已知化合物（2 - 8）。新化合物和已知化合物的结构是根据光谱证据确定的，尤其是通过二维核磁共振（1H-1H COSY、NOESY、HMQC、HMBC）。此外，采用气相色谱-质谱联用（GC-MS）对长叶海榄雌叶的挥发性成分进行了分析。鉴定出25种成分，约占挥发油的96%，其中柠檬烯（17.50%）、吉马烯D（16.60%）、榄香醇（11.81%）、双环吉马烯（11.67%）、愈创醇（11.53）和表-α-红没药醇（7.24%）是含量最高的成分。生物自显影显示，该挥发油对一些革兰氏阳性菌和革兰氏阴性菌具有生物活性。