Warner-Smith Matthew, Darke Shane, Day Carolyn
National Drug and Alcohol Research Centre, University of New South Wales, NSW, Australia.
Addiction. 2002 Aug;97(8):963-7. doi: 10.1046/j.1360-0443.2002.00132.x.
To estimate the range and severity of heroin overdose related morbidity.
Cross-sectional survey.
Sydney, Australia.
198 heroin users.
Sixty-nine per cent had experienced a heroin overdose, 28% in the preceding 12 months. Of those who had overdosed, 79% had experienced at least one overdose-related morbidity symptom. An ambulance had attended overdoses for 59% of subjects, 33% had required hospital treatment for overdose, and 14% had experienced overdose-related complications of sufficient severity to be admitted to a hospital ward. Indirect overdose-related morbidity included: physical injury sustained when falling at overdose (40%), burns (24%) and assault while unconscious (14%). Direct overdose-related morbidity included: peripheral neuropathy (49%), vomiting (33%), temporary paralysis of limbs (26%), chest infections (13%) and seizure (2%).
There appears to be extensive morbidity associated with non-fatal overdose. This is clearly an area that requires more research to document the prevalence and nature of these harms, and factors associated with them.
评估海洛因过量相关发病情况的范围和严重程度。
横断面调查。
澳大利亚悉尼。
198名海洛因使用者。
69%的人曾有过海洛因过量经历,其中28%在过去12个月内有过。在那些曾过量用药的人中,79%至少经历过一种与过量用药相关的发病症状。59%的受试者过量用药时曾呼叫过救护车,33%因过量用药需要住院治疗,14%经历过严重程度足以入住医院病房的与过量用药相关的并发症。与过量用药间接相关的发病情况包括:过量用药时摔倒所致身体损伤(40%)、烧伤(24%)以及昏迷时遭袭击(14%)。与过量用药直接相关的发病情况包括:周围神经病变(49%)、呕吐(33%)、肢体暂时麻痹(26%)、胸部感染(13%)和癫痫发作(2%)。
非致命性过量用药似乎会引发广泛的发病情况。显然,这是一个需要更多研究来记录这些危害的发生率、性质及其相关因素的领域。