Verigo V V, Sushkov F V, Rudneva S V
Kosm Biol Aviakosm Med. 1975 Sep-Oct;9(5):3-6.
The paper presents a method of building a mathematical model of the time dynamics of the cell population density and mitotic index which allows the prediction of the population growth as related to the cultivation conditions. The process of mammalian cell division has been shown to delay noticeably with a decrease of the cultivation temperature from 36 to 30 degrees C and an increase of the initial population density. The curve of the population density has a typical sigmoidal pattern.
本文提出了一种构建细胞群体密度和有丝分裂指数时间动态数学模型的方法，该模型能够预测与培养条件相关的群体生长情况。研究表明，随着培养温度从36摄氏度降至30摄氏度以及初始群体密度的增加，哺乳动物细胞分裂过程会明显延迟。群体密度曲线呈现出典型的S形模式。
