Viskari Hanna R, Roivainen Merja, Reunanen Antti, Pitkäniemi Janne, Sadeharju Karita, Koskela Pentti, Hovi Tapani, Leinikki Pauli, Vilja Pekka, Tuomilehto Jaakko, Hyöty Heikki
Juvenile Diabetes Foundation International Center for the Prevention of type 1 diabetes in Finland and the Department of Virology, University of Tampere, Medical School, Tampere, Finland.
Diabetes. 2002 Aug;51(8):2568-71. doi: 10.2337/diabetes.51.8.2568.
Previous studies have suggested that enterovirus infections during pregnancy may increase the risk of type 1 diabetes in the offspring. Our aim was to evaluate the role of first trimester enterovirus infections in a larger cohort of pregnant women. Two series of pregnant women were analyzed as follows: 948 women (series 1) and 680 women (series 2) whose child developed clinical diabetes before the ages of 15 or 7 years, respectively. An equal number of control women with a nondiabetic child was selected. Acute enterovirus infections were diagnosed by measuring IgM class antibodies against coxsackievirus B5 (series 1) and a mixture of coxsackievirus B3, coxsackievirus A16, and echovirus 11 antigens (series 2). In series 2, all sera were also analyzed for IgG class antibodies against an enterovirus peptide antigen. In addition, 152 randomly selected case-control pairs and all IgM-positive mothers' sera were tested for enterovirus RNA (series 2). In series 1, 3.1% of case women had IgM antibodies against coxsackievirus B5 antigen compared with 4.1% of control women (NS). In series 2, 7.1% of case and 5.3% of control women had IgM against the mixture of enterovirus antigens (NS). IgG class enterovirus antibodies did not differ between the groups. Enterovirus RNA was found only in one case woman (0.3%) of the subgroup of samples and in 5.7% of 70 IgM-positive women. The results suggest that enterovirus infection during the first trimester of pregnancy is not associated with increased risk for type 1 diabetes in the child.
先前的研究表明，孕期感染肠道病毒可能会增加子代患1型糖尿病的风险。我们的目的是在更大规模的孕妇队列中评估孕早期肠道病毒感染的作用。对两组孕妇进行了如下分析：948名孕妇（第1组）和680名孕妇（第2组），其孩子分别在15岁或7岁之前出现临床糖尿病。选取了数量相等的子代无糖尿病的对照女性。通过检测抗柯萨奇病毒B5的IgM类抗体（第1组）以及抗柯萨奇病毒B3、柯萨奇病毒A16和埃可病毒11抗原混合物的抗体（第2组）来诊断急性肠道病毒感染。在第2组中，还对所有血清进行了抗肠道病毒肽抗原的IgG类抗体分析。此外，对152对随机选取的病例对照和所有IgM阳性母亲的血清进行了肠道病毒RNA检测（第2组）。在第1组中，3.1%的病例女性有抗柯萨奇病毒B5抗原的IgM抗体，而对照女性为4.1%（无统计学差异）。在第2组中，7.1%的病例女性和5.3%的对照女性有抗肠道病毒抗原混合物的IgM（无统计学差异）。两组之间IgG类肠道病毒抗体无差异。仅在样本亚组的1例病例女性（0.3%）和70例IgM阳性女性的5.7%中发现了肠道病毒RNA。结果表明，孕早期肠道病毒感染与子代患1型糖尿病的风险增加无关。
