Elfving Maria, Svensson Johan, Oikarinen Sami, Jonsson Björn, Olofsson Per, Sundkvist Göran, Lindberg Bengt, Lernmark Ake, Hyöty Heikki, Ivarsson Sten-Anders
Department of Clinical Sciences, Pediatric Unit, Lund University Hospital, Lund University, 221 85 Lund, Sweden.
Exp Diabetes Res. 2008;2008:271958. doi: 10.1155/2008/271958.
Maternal enterovirus infections during pregnancy may increase the risk of offspring developing type 1 diabetes during childhood. The aim of this study was to investigate whether gestational enterovirus infections increase the offspring's risk of type 1 diabetes later in life. Serum samples from 30 mothers without diabetes whose offspring developed type 1 diabetes between 15 and 25 years of age were analyzed for enterovirus-specific immunoglobulin M (IgM) antibodies and enterovirus genome (RNA), and compared to a control group. Among the index mothers, 9/30 (30%) were enterovirus IgM-positive, and none was positive for enterovirus RNA. In the control group, 14/90 (16%) were enterovirus IgM-positive, and 4/90 (4%) were positive for enterovirus RNA (n.s.). Boys of enterovirus IgM-positive mothers had approximately 5 times greater risk of developing diabetes (OR 4.63; 95% CI 1.22-17.6), as compared to boys of IgM-negative mothers (P < .025). These results suggest that gestational enterovirus infections may be related to the risk of offspring developing type 1 diabetes in adolescence and young adulthood.
孕期母体肠道病毒感染可能会增加子代儿童期患1型糖尿病的风险。本研究的目的是调查孕期肠道病毒感染是否会增加子代日后患1型糖尿病的风险。对30名无糖尿病母亲的血清样本进行分析，这些母亲的子代在15至25岁之间患1型糖尿病，检测样本中肠道病毒特异性免疫球蛋白M（IgM）抗体和肠道病毒基因组（RNA），并与对照组进行比较。在受试母亲中，9/30（30%）肠道病毒IgM呈阳性，无一例肠道病毒RNA呈阳性。在对照组中，14/90（16%）肠道病毒IgM呈阳性，4/90（4%）肠道病毒RNA呈阳性（无统计学差异）。与IgM阴性母亲的男孩相比，肠道病毒IgM阳性母亲的男孩患糖尿病的风险大约高5倍（比值比4.63；95%可信区间1.22 - 17.6）（P <.025）。这些结果表明，孕期肠道病毒感染可能与子代在青春期和成年早期患1型糖尿病的风险有关。
