前列腺素在血管系统中的调节作用。
Regulatory role of prostaglandins in the vascular system.
作者信息
Gryglewski R, Grodzińska L, Korbut R, Ocetkiewicz A, Panczenko B
出版信息
Mater Med Pol. 1975 Oct-Dec;7(4):314-21.
PMID:1214520
Abstract
It is reported that noradrenaline-induced vasoconstriction initiates generation of prostaglandins of the E series by vasculas walls. These endogenous prostaglandins attenuate the vasoconstrictor effect of noradrenaline. Inhibitors of prostaglandin biosynthesis (indomethacin, mefenamic acid) abolish acute tolerance to noradrenaline infusions and counteract hypotension which is induced in cats by injection of endotoxin or by injection of rat blood.
摘要
据报道，去甲肾上腺素诱导的血管收缩会引发血管壁产生E系列前列腺素。这些内源性前列腺素会减弱去甲肾上腺素的血管收缩作用。前列腺素生物合成抑制剂（吲哚美辛、甲芬那酸）可消除对去甲肾上腺素输注的急性耐受性，并对抗由注射内毒素或大鼠血液诱导猫产生的低血压。
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