Bansal Rashmi
Department of Neuroscience, University of Connecticut School of Medicine, Farmington 06030-3401, USA.
Dev Neurosci. 2002;24(1):35-46. doi: 10.1159/000064944.
Fibroblast growth factors are a family of broad-spectrum growth factors influencing a plethora of cellular activities. The interaction of at least 23 ligands, 4 receptors and multiple coreceptors provides a dramatic complexity to a signaling system capable of effecting a multitude of responses. This review focuses on the fibroblast growth factors signaling in oligodendrocyte development, function and discusses implications for demyelination/remyelination.
成纤维细胞生长因子是一类影响众多细胞活动的广谱生长因子。至少23种配体、4种受体和多种共受体之间的相互作用，为一个能够产生多种反应的信号系统带来了极大的复杂性。本综述聚焦于成纤维细胞生长因子在少突胶质细胞发育和功能中的信号传导，并讨论其对脱髓鞘/再髓鞘化的影响。
