Deroo-Berger M C, Skowron F, Ronger S, Balme B, Berard F, Causeret A S, Perrot H, Thomas L
Dermatology Unit, Hôtel-Dieu, Lyon, France.
Dermatology. 2002;205(1):60-2. doi: 10.1159/000063132.
We report a localized form of lymphomatoid papulosis (LyP) presenting as pustular papules of the hands. The histopathology revealed a moderate inflammatory infiltrate composed of atypical pleomorphic large lymphocytes with atypical mitosis and large nuclei. Epidermotropism could be observed. These atypical cells expressed CD4 and CD30. Laboratory examinations and bone marrow explorations remained negative. The clinical presentation of this case of LyP is unusual. Only histopathological features allowed to diagnose LyP. The knowledge that LyP may be associated with neoplasia or lymphoma underlines the need for a long-term follow-up of these patients.
我们报告了一例局限型淋巴瘤样丘疹病（LyP），表现为手部脓疱性丘疹。组织病理学显示有中度炎症浸润，由具有非典型有丝分裂和大细胞核的非典型多形性大淋巴细胞组成。可见向表皮性。这些非典型细胞表达CD4和CD30。实验室检查和骨髓检查均为阴性。该例LyP的临床表现不寻常。仅靠组织病理学特征才能诊断LyP。LyP可能与肿瘤或淋巴瘤相关这一认识强调了对这些患者进行长期随访的必要性。
