Schumpelick V
Langenbecks Arch Chir. 1975 Sep 10;338(4):265-74. doi: 10.1007/BF01261716.
The influence of bile on the ulcer formation under "restraint stress" condition was studied in rats with direct choledocho-gastrostomia resp. bile duct ligation. After 9 hrs. of immobilisation in plaster cuffs the animals with unrestricted bile flow via the choledochosstress gastrostomia showed as many ulcers as the sham-operated controls. There was no difference in the ulcer localisation, the region of the bile duct anastomosis was without any ulcer. After bile duct ligation the ulcer frequency was reduced to the half. These results are explained by a massive bile reflux under stress condition, of which the pathogenetic role in stress ulcer formation is discussed.
通过直接胆总管-胃吻合术或胆管结扎术，研究了胆汁对“束缚应激”条件下大鼠溃疡形成的影响。在石膏袖套中固定9小时后，通过胆总管-胃吻合术胆汁流动不受限制的动物出现的溃疡数量与假手术对照组相同。溃疡定位没有差异，胆管吻合区域没有任何溃疡。胆管结扎后溃疡发生率降至一半。这些结果可以用应激条件下大量胆汁反流来解释，文中讨论了其在应激性溃疡形成中的致病作用。
