Apte Ron N, Voronov Elena
Department of Microbiology and Immunology, Faculty of Health Sciences and The Cancer Research Center, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
Semin Cancer Biol. 2002 Aug;12(4):277-90. doi: 10.1016/s1044-579x(02)00014-7.
Interleukin-1 (IL-1) represents a family of two agonistic proteins, IL-1alpha and IL-1beta, that are pleiotropic and affect hemopoiesis, inflammation, and immunity. In the context of the producing cell, IL-1beta is solely active in its secreted form, whereas IL-1alpha is active as an intracellular precursor, as a membrane-associated cytokine and to a lesser extent as a secreted molecule. IL-1 is abundant at tumor sites, where it may not only affect the growth and invasiveness of malignant cells, but where it may also induce antitumor immunity. Here we review the effects of microenvironmental and tumor cell-associated IL-1 on malignant processes, in experimental tumor models and in cancer patients.
白细胞介素-1（IL-1）是由两种具有激动作用的蛋白质——IL-1α和IL-1β组成的家族，具有多效性，可影响造血、炎症和免疫。在产生细胞的背景下，IL-1β仅以其分泌形式具有活性，而IL-1α作为细胞内前体、膜相关细胞因子具有活性，在较小程度上也作为分泌分子具有活性。IL-1在肿瘤部位大量存在，在那里它不仅可能影响恶性细胞的生长和侵袭性，还可能诱导抗肿瘤免疫。在此，我们综述了实验性肿瘤模型和癌症患者中，微环境和肿瘤细胞相关的IL-1对恶性过程的影响。
