白细胞介素-1受体拮抗剂：一种对抗人类鳞状细胞癌的有前景的细胞因子。
Interleukin-1 receptor antagonist: a promising cytokine against human squamous cell carcinomas.
作者信息
Ding Yujie, Yi Jie, Wang Jinxin, Sun Zhida
机构信息
Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu, China.
Department of Oral Medicine, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, Jiangsu, China.
出版信息
Heliyon. 2023 Mar 28;9(4):e14960. doi: 10.1016/j.heliyon.2023.e14960. eCollection 2023 Apr.
Abstract
Inflammation, especially chronic inflammation, is closely linked to tumor development. As essential chronic inflammatory cytokines, the interleukin family plays a key role in inflammatory infections and malignancies. The interleukin-1 (IL-1) receptor antagonist (IL1RA), as a naturally occurring receptor antagonist, is the first discovered and can compete with IL-1 in binding to the receptor. Recent studies have revealed the association of the polymorphisms in IL1RA with an increased risk of squamous cell carcinomas (SCCs), including squamous cell carcinoma of the head and neck (SCCHN), cervical squamous cell carcinoma, cutaneous squamous cell carcinoma (cSCC), esophageal squamous cell carcinoma (ESCC), and bronchus squamous cell carcinoma. Here, we reviewed the antitumor potential of IL1RA as an IL-1-targeted inhibitor.
摘要
炎症，尤其是慢性炎症，与肿瘤发展密切相关。作为重要的慢性炎症细胞因子，白细胞介素家族在炎症感染和恶性肿瘤中起关键作用。白细胞介素-1（IL-1）受体拮抗剂（IL1RA）作为一种天然存在的受体拮抗剂，是最早被发现的，并且能够与IL-1竞争结合受体。最近的研究揭示了IL1RA基因多态性与鳞状细胞癌（SCC）风险增加之间的关联，包括头颈部鳞状细胞癌（SCCHN）、宫颈鳞状细胞癌、皮肤鳞状细胞癌（cSCC）、食管鳞状细胞癌（ESCC）和支气管鳞状细胞癌。在此，我们综述了IL1RA作为一种靶向IL-1的抑制剂的抗肿瘤潜力。
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