Seo Naohiro, Hayakawa Satoshi, Tokura Yoshiki
Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handa-Yama, Hamamatsu, Shizuoka 431-3192, Japan.
Semin Cancer Biol. 2002 Aug;12(4):291-300. doi: 10.1016/s1044-579x(02)00015-9.
In murine tumors, innate immunity act as a trigger for the development of acquired immunity. The innate immune cells, natural killer (NK) and natural T (NKT) cells, generate the acquired immune cells, cytotoxic T lymphocytes (CTLs) and T helper (Th) 1 cells, by releasing interferon (IFN)-gamma. Regulatory T cells co-infiltrate with these tumoricidal effectors. In the innate phase, T cell receptor (TCR) gammadelta-bearing T (gammadelta T) and TCRalphabeta intermediate T cells are the regulators that suppress NK and NKT cells by elaborating interleukin (IL)-4, IL-10 and transforming growth factor (TGF)-beta. The acquired phase has Th3/T regulatory 1-like cells that inhibit CTLs and Th1 cells by TGF-beta. Thus, cytokines from regulatory T cells exert profound effects on tumor growth.
在鼠类肿瘤中，先天免疫充当获得性免疫发展的触发因素。先天免疫细胞，即自然杀伤（NK）细胞和自然T（NKT）细胞，通过释放γ干扰素产生获得性免疫细胞，即细胞毒性T淋巴细胞（CTL）和辅助性T（Th）1细胞。调节性T细胞与这些杀肿瘤效应细胞共同浸润。在先天阶段，携带γδT细胞受体（TCR）的γδT细胞和TCRαβ中间型T细胞是通过分泌白细胞介素（IL）-4、IL-10和转化生长因子（TGF）-β来抑制NK细胞和NKT细胞的调节细胞。在获得性阶段，有Th3/调节性T1样细胞通过TGF-β抑制CTL和Th1细胞。因此，来自调节性T细胞的细胞因子对肿瘤生长产生深远影响。
