Dzik-Jurasz Andrzej, Domenig Claudia, George Mark, Wolber Jan, Padhani Anwar, Brown Gina, Doran Simon
UK Cancer Research Clinical Magnetic Resonance Research Group, Institute of Cancer Research, Royal Marsden NHS Trust, Downs Road, Sutton SM2 5PT, UK.
Lancet. 2002 Jul 27;360(9329):307-8. doi: 10.1016/S0140-6736(02)09520-X.
Prediction of tumour response before onset of treatment could have considerable clinical benefit. Since the apparent diffusion coefficient (ADC) of a tumour's water content can show the extent of necrosis, we looked for a possible correlation of ADC with response to treatment. We measured mean tumour water ADC before and after chemotherapy and chemoradiation in 14 patients with locally advanced rectal cancer, with a quantitative magnetic resonance diffusion imaging sequence. We found a strong negative correlation between mean pretreatment tumour water ADC and percentage size change of tumours after chemotherapy (r=-0.67, p=0.01) and chemoradiation (r=-0.83, p=0.001). Persistence of low ADC in responders after chemotherapy could represent loss of a non-viable fraction of the treated tumour.
在治疗开始前预测肿瘤反应可能具有相当大的临床益处。由于肿瘤含水量的表观扩散系数（ADC）可以显示坏死程度，我们探寻了ADC与治疗反应之间可能存在的相关性。我们使用定量磁共振扩散成像序列，测量了14例局部晚期直肠癌患者化疗及放化疗前后肿瘤水的平均ADC值。我们发现，化疗前肿瘤水的平均ADC值与化疗后（r=-0.67，p=0.01）及放化疗后（r=-0.83，p=0.001）肿瘤大小变化百分比之间存在强负相关。化疗后反应者中低ADC值的持续存在可能代表已治疗肿瘤中非存活部分的丧失。
