Liu Y, Bai R, Sun H, Liu H, Zhao X, Li Y
Department of Radiology, General Hospital of Tianjin Medical University, Tianjin, China.
Clin Radiol. 2009 Nov;64(11):1067-74. doi: 10.1016/j.crad.2009.07.010.
To investigate the ability of diffusion-weighted imaging (DWI) to predict and monitor the response of uterine cervical cancer to combined chemoradiation using apparent diffusion coefficients (ADCs).
Seventeen women (mean age 48.5 years) with uterine cervical cancer received conventional magnetic resonance imaging (MRI) and DWI prior to chemoradiation and after 1 and 2 months of therapy. A subgroup of eight also had MRI and DWI repeated after 15 days of therapy. Treatment response was determined according to changes in tumour size after 2 months of therapy and was classified as complete response (CR), partial response (PR), stable disease (SD), or progressive disease (PD). Pretreatment ADCs were compared between the different disease response groups, and dynamic changes of ADCs in each group were observed. Pearson's correlation test was calculated between those ADC parameters and tumour response.
Pretreatment ADCs for CR were significantly lower than those of PR (p=0.005). Negative correlation was found between pretreatment ADCs and percentage size reduction after 2 months of chemoradiation (p=0.016). The percentage ADC change after 1 month correlated positively with percentage size reduction after 2 months of therapy (p=0.021). ADCs after 15 days of therapy increased significantly compared with pretreatment ones (p=0.001); however, the longest tumour diameter showed no statistically significant change (p=0.078).
ADCs may have the potential to be used to predict and monitor the response of uterine cervical cancer to therapy.
利用表观扩散系数（ADC）研究扩散加权成像（DWI）预测和监测子宫颈癌对同步放化疗反应的能力。
17例子宫颈癌患者（平均年龄48.5岁）在同步放化疗前、治疗1个月和2个月后接受了常规磁共振成像（MRI）和DWI检查。其中8例患者在治疗15天后也重复进行了MRI和DWI检查。根据治疗2个月后肿瘤大小的变化确定治疗反应，并分为完全缓解（CR）、部分缓解（PR）、疾病稳定（SD）或疾病进展（PD）。比较不同疾病反应组之间的治疗前ADC值，观察每组ADC值的动态变化。计算这些ADC参数与肿瘤反应之间的Pearson相关性检验。
CR组的治疗前ADC值显著低于PR组（p=0.005）。治疗前ADC值与同步放化疗2个月后肿瘤大小缩小百分比呈负相关（p=0.016）。治疗1个月后的ADC变化百分比与治疗2个月后的肿瘤大小缩小百分比呈正相关（p=0.021）。治疗15天后的ADC值与治疗前相比显著增加（p=0.001）；然而，肿瘤最长直径无统计学显著变化（p=0.078）。
ADC值可能具有预测和监测子宫颈癌治疗反应的潜力。
