血管生成、血小板反应蛋白与乳腺导管原位癌
Angiogenesis, thrombospondin, and ductal carcinoma in situ of the breast.
作者信息
Rice A, Quinn C M
机构信息
Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK.
出版信息
J Clin Pathol. 2002 Aug;55(8):569-74. doi: 10.1136/jcp.55.8.569.
Abstract
Angiogenesis, the growth of new vessels from existing vasculature, plays an essential role in tumour development. The process involves interaction between a variety of cells, growth factors, and components of the extracellular matrix, regulated by pro-angiogenic and anti-angiogenic factors. This review profiles these factors, outlines the available methods for measuring new vessel formation, and discusses the importance of angiogenesis in breast cancer, with emphasis on ductal carcinoma in situ.
摘要
血管生成，即从现有脉管系统生长出新的血管，在肿瘤发展过程中起着至关重要的作用。该过程涉及多种细胞、生长因子和细胞外基质成分之间的相互作用，由促血管生成因子和抗血管生成因子调控。本综述介绍了这些因子，概述了测量新血管形成的现有方法，并讨论了血管生成在乳腺癌中的重要性，重点是原位导管癌。
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