Demirci Hakan, Gezer Acun, Sezen Fazil, Ovali Tunc, Demiralp Tamer, Isoglu-Alkoc Ummuhan
Department of Ophthalmology, Istanbul University, Istanbul Faculty of Medicine, Turkey.
J Pediatr Ophthalmol Strabismus. 2002 Jul-Aug;39(4):215-21. doi: 10.3928/0191-3913-20020701-09.
To evaluate the functions of the magnocellular and parvocellular pathways in strabismic amblyopia.
Visual evoked potentials produced by achromatic and chromatic stimuli in 14 children with strabismic amblyopia were compared with those in 14 age-matched control subjects. The achromatic sine-wave grating with low spatial frequency was used to stimulate the magnocellular pathway, whereas the parvocellular pathway was stimulated by the chromatic sine-wave grating (isoluminant red-green) with low and high spatial frequencies.
When the achromatic stimuli with low spatial frequency were used, the latencies of the N1 and P1 components and the amplitude of the N1-P1 complex were similar in the children with strabismic amblyopia and the control subjects. There also were no differences between the amblyopic and non-amblyopic eyes of the children with strabismic amblyopia. When chromatic stimuli with low and high spatial frequencies were used, the latencies of the N1 and P1 components were significantly longer and the amplitude of the N1-P1 complex was significantly smaller in the children with strabismic amblyopia than in the control group. When the amblyopic and non-amblyopic eyes of the children with strabismic amblyopia were compared, the latencies of the N1 and P1 components were longer and the amplitude of the N1-P1 complex was smaller in the amblyopic eyes.
In strabismic amblyopia, the cells in the parvocellular pathway may be more involved, whereas the magnocellular pathway may be relatively spared.
评估斜视性弱视中大细胞和小细胞通路的功能。
将14例斜视性弱视儿童由无色和彩色刺激产生的视觉诱发电位与14例年龄匹配的对照受试者的进行比较。使用低空间频率的无色正弦波光栅刺激大细胞通路，而小细胞通路则由低空间频率和高空间频率的彩色正弦波光栅（等亮度红-绿）刺激。
当使用低空间频率的无色刺激时，斜视性弱视儿童和对照受试者中N1和P1成分的潜伏期以及N1-P1复合波的振幅相似。斜视性弱视儿童的弱视眼和非弱视眼之间也没有差异。当使用低空间频率和高空间频率的彩色刺激时，斜视性弱视儿童中N1和P1成分的潜伏期明显更长，N1-P1复合波的振幅明显小于对照组。比较斜视性弱视儿童的弱视眼和非弱视眼时，弱视眼中N1和P1成分的潜伏期更长，N1-P1复合波的振幅更小。
在斜视性弱视中，小细胞通路中的细胞可能受累更多，而大细胞通路可能相对未受影响。
