Richardson Madalene, Carroll Nora M, Engelke Erica, Van Der Spuy Gian D, Salker Faeeza, Munch Zahn, Gie Robert P, Warren Robin M, Beyers Nulda, Van Helden Paul D
MRC Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa.
J Clin Microbiol. 2002 Aug;40(8):2750-4. doi: 10.1128/JCM.40.8.2750-2754.2002.
In an ongoing molecular epidemiology study, human immunodeficiency virus-negative patients with first-time pulmonary tuberculosis from a high-incidence community were enrolled. Mycobacterium tuberculosis strains were identified by restriction fragment length polymorphism analysis with two fingerprinting probes. Of 131 patients, 3 (2.3%) were shown to have a mixture of strains in one or two of their serial cultures. This study further investigated these cases with disease caused by multiple M. tuberculosis strains in the context of the molecular epidemiology of the study setting.
在一项正在进行的分子流行病学研究中,纳入了来自高发病率社区的首次患肺结核的人类免疫缺陷病毒阴性患者。采用两种指纹探针通过限制性片段长度多态性分析鉴定结核分枝杆菌菌株。在131例患者中,有3例(2.3%)在其一或两次连续培养物中显示有菌株混合。本研究在该研究背景下的分子流行病学中进一步调查了这些由多种结核分枝杆菌菌株引起疾病的病例。