Meyer Hermann, Perrichot Mathilde, Stemmler Markus, Emmerich Petra, Schmitz Herbert, Varaine Francis, Shungu Robert, Tshioko Florimond, Formenty Pierre
Institute of Microbiology, German Armed Forces Medical Academy, Munich, Switzerland.
J Clin Microbiol. 2002 Aug;40(8):2919-21. doi: 10.1128/JCM.40.8.2919-2921.2002.
Seven outbreaks of disease characterized by a pustular rash and suspected to have been caused by human monkeypox virus were investigated. The outbreaks occurred between February and August 2001 in the province of Equateur in the Democratic Republic of Congo. The outbreaks involved a total of 31 persons and caused five deaths. Specimens from 14 patients were available and were analyzed by electron microscopy, virus isolation, and PCR assays specific for monkeypox virus and varicella-zoster virus. We provide evidence that two outbreaks were indeed caused by monkeypox virus (16 cases, with four deaths), that in two outbreaks both monkeypox and varicella-zoster virus were involved (seven cases, with one death), and that two outbreaks were cases of chickenpox caused by infection with varicella-zoster virus (six cases, with no deaths). In one outbreak, no evidence for either monkeypox or chickenpox was found (two cases, with no deaths).
对七起以脓疱性皮疹为特征、疑似由人猴痘病毒引起的疾病暴发进行了调查。这些暴发于2001年2月至8月间在刚果民主共和国赤道省发生。暴发共涉及31人，造成5人死亡。从14名患者身上获取了标本，并通过电子显微镜检查、病毒分离以及针对猴痘病毒和水痘-带状疱疹病毒的聚合酶链反应检测进行分析。我们提供的证据表明，两起暴发确实由猴痘病毒引起（16例，4人死亡），两起暴发涉及猴痘病毒和水痘-带状疱疹病毒（7例，1人死亡），两起暴发是由水痘-带状疱疹病毒感染引起的水痘病例（6例，无死亡）。在一次暴发中，未发现猴痘或水痘的证据（2例，无死亡）。
