Soleimani S, Motamed N
Razi Vaccine & Serum Research Institute, Agricultural Research Education and Extension Organization (AREEO), P.O. Box 31975-148, Karaj, Iran.
Arch Razi Inst. 2024 Dec 31;79(6):1121-1133. doi: 10.32592/ARI.2024.79.6.1121. eCollection 2024 Dec.
Monkey pox has recently garnered significant attention due to the proliferation of re-emerging and emerging infectious diseases, particularly epidemic-scale outbreaks. Mpox was initially identified as a discrete illness in 1958 among laboratory monkeys in Copenhagen, Denmark. The initial case of monkey pox infection in humans was documented in 1970 in the Democratic Republic of the Congo. The patient was a nine-month-old boy who was the sole member of his family to lack smallpox vaccination. The monkey pox virus is a zoonotic virus belonging to the family Poxviridae, subfamily Chordopoxvirinae, and genus Orthopoxvirus. Transmission of monkey pox occurs via direct contact with an infected individual or surface. Additionally, transmission between humans can occur via the bodily fluids of an infected individual. This review article addresses all aspects of this disease, beginning with an introduction, history, virology, clinical features, and complications. It then turns to clinical differential diagnosis with similar diseases, epidemiology, prevalence, animal hosts, virus transmission, disease diagnosis, prevention and treatment, and finally, future risks. In light of the aforementioned considerations, this article presents a comprehensive review of the various facets of the disease, offering a valuable resource for researchers and policymakers in the domains of health and public health. The article's insights into the disease's characteristics, its impact on human and animal health, and its potential as a zoonotic disease underscore the importance of disease prevention.
由于重新出现和新出现的传染病不断扩散,尤其是出现了大规模流行疫情,猴痘最近受到了广泛关注。猴痘最初于1958年在丹麦哥本哈根的实验猴中被确认为一种独立的疾病。1970年在刚果民主共和国记录了首例人类猴痘感染病例。患者是一名9个月大的男孩,是其家庭中唯一未接种天花疫苗的成员。猴痘病毒是一种人畜共患病毒,属于痘病毒科、脊索痘病毒亚科和正痘病毒属。猴痘的传播途径包括直接接触受感染的个体或表面。此外,人与人之间的传播可通过受感染个体的体液发生。这篇综述文章探讨了该疾病的各个方面,首先是引言、历史、病毒学、临床特征和并发症。接着转向与类似疾病的临床鉴别诊断、流行病学、患病率、动物宿主、病毒传播、疾病诊断、预防和治疗,最后是未来风险。鉴于上述考虑因素,本文对该疾病的各个方面进行了全面综述,为健康和公共卫生领域的研究人员和政策制定者提供了宝贵的资源。文章对该疾病特征、对人类和动物健康的影响以及作为人畜共患疾病的潜力的见解,凸显了疾病预防的重要性。