Schreiner U, Schroeder-Boersch H, Schwarz M, Scheller G
Orthopädische Universitätsklinik Mannheim.
Biomed Tech (Berl). 2002 Jun;47(6):164-8.
The aim of this experimental study was to screen different surface structures of alumina and zirconia ceramic implants for their osteointegration properties. Alumina and zirconia ceramic test implants having different surface structures (smooth, macro-structured, corundum-blasted, porous) were implanted in the femora of mini-pigs, and left in situ for 12 weeks. After removal, the implants were evaluated macroradiographically and histologically. The smooth and macro-structured ceramic surfaces showed virtually no bony ingrowth, neither in the cortical nor the cancellous bone areas. In contrast, a rough surface finish or a porous surface structure allowed extensive bony ingrowth. The osteointegration rates varied between 20.5% and 41.7% (cancellous bone), and between 26.0% and 52.8% (cortical bone). With regard to the development of ceramic implants for clinical use, for example in the field of total hip replacement, these data provide a basis for further, more comprehensive studies.
本实验研究的目的是筛选具有不同表面结构的氧化铝和氧化锆陶瓷植入物的骨整合特性。将具有不同表面结构（光滑、宏观结构、刚玉喷砂、多孔）的氧化铝和氧化锆陶瓷测试植入物植入小型猪的股骨中，并原位留置12周。取出后，对植入物进行大体X线摄影和组织学评估。光滑和宏观结构的陶瓷表面在皮质骨和松质骨区域几乎均未显示出骨长入。相比之下，粗糙的表面光洁度或多孔的表面结构允许广泛的骨长入。骨整合率在20.5%至41.7%（松质骨）之间，以及在26.0%至52.8%（皮质骨）之间。关于临床用陶瓷植入物的开发，例如在全髋关节置换领域，这些数据为进一步更全面的研究提供了基础。
