Basaria S, Salvatori R
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
J Endocrinol Invest. 2002 Jul-Aug;25(7):639-42. doi: 10.1007/BF03345090.
Thyrotoxicosis resulting from functional thyroid cancer metastases is extremely rare, and is mostly caused by follicular cancer. The lesions causing thyrotoxicosis are usually bulky and extensive. We report here a patient with Graves' disease and concomitant papillary thyroid cancer who developed metastases causing symptomatic thyrotoxicosis. His serum titers of thyroid stimulating Ig (TSIs) were elevated. We believe that TSIs were responsible for thyrotoxicosis by stimulating hormonogenesis in the metastatic lesions.
功能性甲状腺癌转移导致的甲状腺毒症极为罕见，且大多由滤泡状癌引起。导致甲状腺毒症的病变通常体积较大且范围广泛。我们在此报告一例患有格雷夫斯病并伴有甲状腺乳头状癌的患者，其发生转移导致了有症状的甲状腺毒症。他的甲状腺刺激免疫球蛋白（TSIs）血清滴度升高。我们认为TSIs通过刺激转移病灶中的激素生成导致了甲状腺毒症。
