Oppenheim A, Miller M, Anderson G H, Davis B, Slagle T
Am J Med. 1983 Oct;75(4):702-4. doi: 10.1016/0002-9343(83)90460-6.
Primary thyroid malignancies typically do not interfere with thyroid function. A patient is reported with anaplastic thyroid carcinoma presenting with hyperthyroidism; this is believed to be the first such case described. Prior to the onset of the thyroidal process, the patient was clinically euthyroid. It is concluded that the mechanism of thyrotoxicosis is analogous to that of subacute thyroiditis: rapid tissue necrosis with resultant release of thyroid hormone.
原发性甲状腺恶性肿瘤通常不会影响甲状腺功能。据报道，有一名患者患间变性甲状腺癌并伴有甲状腺功能亢进；据信这是首例此类报道病例。在甲状腺疾病发作之前，该患者临床上甲状腺功能正常。得出的结论是，甲状腺毒症的机制与亚急性甲状腺炎类似：组织迅速坏死，导致甲状腺激素释放。
