Coleman Michael J, Cook Samantha, Matthysse Steven, Barnard John, Lo Yungtai, Levy Deborah L, Rubin Donald B, Holzman Philip S
Psychology Research Laboratory, Mailman Research Center, McLean Hospital, Belmont, Massachusetts 02478, USA.
J Abnorm Psychol. 2002 Aug;111(3):425-35. doi: 10.1037//0021-843x.111.3.425.
This study reports evidence that schizophrenia patients are significantly impaired in both spatial and object (shape) working memory. A 3-s delay between exposure and recall of targets was used and Bayesian item-response theory was applied to compensate for the tasks' differential difficulty while simultaneously taking account of missing data from participant attrition. Weaker evidence was found that in schizophrenia both domains are equally impaired on average, that spatial and object working memory appear to be more highly correlated with each other in the schizophrenia population than in the normal population, and that schizophrenia patients show greater variability in spatial than object working memory performance.
本研究报告了证据表明，精神分裂症患者在空间和客体（形状）工作记忆方面均存在显著损害。在目标呈现与回忆之间设置了3秒的延迟，并应用贝叶斯项目反应理论来补偿任务的不同难度，同时考虑到因参与者流失而产生的缺失数据。有较弱的证据表明，在精神分裂症中，平均而言这两个领域的损害程度相同；与正常人群相比，精神分裂症患者群体中空间工作记忆和客体工作记忆之间的相关性似乎更高；并且精神分裂症患者在空间工作记忆表现上比客体工作记忆表现出更大的变异性。
