Navarro-Alarcón M, López-Ga de la Serrana H, Pérez-Valero V, López-Martínez M C
Department of Nutrition and Bromatology, Faculty of Pharmacy, University of Granada, Spain.
Sci Total Environ. 2002 May 27;291(1-3):135-41. doi: 10.1016/s0048-9697(01)01088-9.
Serum concentrations were measured in individuals (n = 50) with liver diseases (cirrhosis and hepatitis) by hydride generation atomic absorption spectrometry in a cross-sectional study. Mean serum selenium levels determined in patients with cirrhosis (n = 12) or with hepatitis (n = 38) were significantly lower (P<0.01) than those measured in control groups mainly due to a decreased liver function. Mean serum selenium concentrations were significantly lower in cirrhotic individuals when compared with patients with hepatitis (P<0.05). Therefore, the severity of the live injury is a factor conditioning the impairment in the selenium body status observed in individuals with hepatopathies. In hepatic patients serum total cholesterol levels showed a significant correlation with serum selenium concentrations (r=0.912, P<0.05) demonstrating the important role of selenium as an antioxidant agent; similarly, gamma-glutamic-transferase levels were significantly correlated with the serum selenium levels (r=-0.803, P<0.05) indicating that when the intensity of the hepatic injury increases (enhancement in serum GGT levels) concomitantly the serum selenium levels decrease significantly. No significant relationships between serum selenium levels and sex or age of patients were observed.
在一项横断面研究中，通过氢化物发生原子吸收光谱法对患有肝脏疾病（肝硬化和肝炎）的个体（n = 50）进行了血清浓度测量。肝硬化患者（n = 12）或肝炎患者（n = 38）的平均血清硒水平显著低于对照组（P<0.01），这主要是由于肝功能下降所致。与肝炎患者相比，肝硬化患者的平均血清硒浓度显著更低（P<0.05）。因此，肝损伤的严重程度是影响肝病患者体内硒状态受损的一个因素。在肝病患者中，血清总胆固醇水平与血清硒浓度呈显著相关性（r = 0.912，P<0.05），这表明硒作为抗氧化剂的重要作用；同样，γ-谷氨酰转移酶水平与血清硒水平显著相关（r = -0.803，P<0.05），这表明当肝损伤强度增加（血清GGT水平升高）时，血清硒水平会显著下降。未观察到血清硒水平与患者性别或年龄之间存在显著关系。
