在浮石修饰碳糊电极上用差分脉冲吸附伏安法测定药物制剂和尿液中的盐酸普鲁卡因
Differential pulse adsorption voltammetry for determination of procaine hydrochloride at a pumice modified carbon paste electrode in pharmaceutical preparations and urine.
作者信息
Wang Cheng Yin, Hu Xiao Ya, Jin Gen Di, Leng Zong Zhou
机构信息
Department of Chemistry and Chemical Engineering, Yangzhou University, 225002, Yangzhou, People's Republic of China.
出版信息
J Pharm Biomed Anal. 2002 Aug 22;30(1):131-9. doi: 10.1016/s0731-7085(02)00204-2.
Procaine hydrochloride was determined by the differential pulse voltammetry (DPV) using a 6% (m/m) pumice modified carbon paste electrode in 1.25 x 10(-3) mol x l(-1) KH(2)PO(4) and Na(2)HPO(4) buffer solution (pH 6.88, 25 degrees C). The anodic peak potential used was +0.980 V (vs. SCE). A good linear relationship was realized between the anodic peak current and procaine concentration in the range of 9.0 x 10(-7)-2.6 x 10(-5) mol x l(-1) with the detection limit of 5.0 x 10(-8) mol x l(-1). The recovery was 95.2-104.8% with the relative standard deviation of 3.2% (n=10). The pharmaceutical preparations, procaine hydrochloride injection and the urine samples were determined with the desirable results.
采用微分脉冲伏安法（DPV），在6%（m/m）浮石修饰碳糊电极、1.25×10⁻³ mol·L⁻¹ KH₂PO₄ 和Na₂HPO₄ 缓冲溶液（pH 6.88，25℃）条件下测定盐酸普鲁卡因。所用阳极峰电位为+0.980 V（vs. SCE）。在9.0×10⁻⁷ - 2.6×10⁻⁵ mol·L⁻¹范围内，阳极峰电流与盐酸普鲁卡因浓度呈良好的线性关系，检测限为5.0×10⁻⁸ mol·L⁻¹。回收率为95.2% - 104.8%，相对标准偏差为3.2%（n = 10）。该方法用于测定盐酸普鲁卡因注射液等药物制剂及尿液样品，结果满意。
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