Wang You-Chu, Georghiou Paris E
Department of Chemistry, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada A1B 3X7.
Org Lett. 2002 Aug 8;4(16):2675-8. doi: 10.1021/ol0261635.
[structure: see text] The first enantioselective total synthesis of (-)-tejedine (1) is reported. Tejedine is a seco-bisbenzyltetrahydroisoquinoline isolated in 1998 as a minor component from Berberis vulgaris. The synthesis was achieved using a strategy employing four key steps, including a chiral auxiliary-assisted diastereoselective Bischler-Napieralski cyclization.
报道了(-)-特吉定(1)的首次对映选择性全合成。特吉定是1998年从普通小檗中分离出的一种次要成分，属于开链双苄基四氢异喹啉类。该合成通过采用包含四个关键步骤的策略实现，其中包括手性助剂辅助的非对映选择性比施勒-纳皮耶拉尔斯基环化反应。
