通过Heck-羟醛环化反应制备的受保护茚满酮。
Protected indanones by a Heck-aldol annulation reaction.
作者信息
Bengtson Anna, Larhed Mats, Hallberg Anders
机构信息
Department of Organic Pharmaceutical Chemistry, Uppsala University, BMC, Box-574, SE-751 23 Uppsala, Sweden.
出版信息
J Org Chem. 2002 Aug 9;67(16):5854-6. doi: 10.1021/jo025756q.
PMID:12153293
Abstract
Monoprotected 3-hydroxyindan-1-ones have been prepared in moderate to good yields by a new tandem reaction involving salicylaldehyde triflates and commercially available 2-hydroxyethyl vinyl ether. This one-pot annulation reaction proceeds in the presence of a palladium bidentate catalyst and results in the formation of two new ring systems.
摘要
通过一种涉及水杨醛三氟甲磺酸酯和市售2-羟乙基乙烯基醚的新型串联反应，已以中等至良好的产率制备了单保护的3-羟基茚满-1-酮。这种一锅环化反应在钯双齿催化剂存在下进行，并导致形成两个新的环系。
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