Dowdall J F, Maguire D, McAnena O J
Department of Surgery, University College Hospital, Galway, Ireland.
Br J Surg. 2002 Aug;89(8):1014-9. doi: 10.1046/j.1365-2168.2002.02158.x.
Results from specialist centres have shown that total mesorectal excision (TME) produces excellent control of local disease in patients with carcinoma of the rectum.
The results of TME were reviewed in a surgical practice in which patients with rectal cancer comprised 1 per cent of the total caseload and mean case numbers were less than 15 each year.
Eighty-two consecutive patients underwent rectal excision with TME over a 72-month period (68 anterior resection, eight abdominoperineal excision and six Hartmann's procedure). Sixty-nine operations were deemed 'curative' at the time of surgery. Anastomotic leak occurred in two (3 per cent) of 68 patients, both of whom recovered without additional surgery. There were two local recurrences (3 per cent) among 69 patients who underwent 'curative' surgery. At a median follow-up of 190 weeks, the survival rate for Dukes' stage A, B, C and 'D' was 100, 83, 68 and 18 per cent respectively.
Outcome as measured by perioperative morbidity and local disease control achieved in a surgical practice with a broad case mix and relatively low annual case volume was comparable to that from larger centres. Appropriate surgical training and attention to technical detail may be as important as case volume in determining outcome after surgery for rectal cancer.
专科中心的研究结果表明,全直肠系膜切除术(TME)能有效控制直肠癌患者的局部疾病。
回顾了一家外科诊所中TME的手术结果,该诊所中直肠癌患者占总病例数的1%,每年平均病例数少于15例。
在72个月的时间里,连续82例患者接受了TME直肠切除术(68例前切除术、8例腹会阴联合切除术和6例Hartmann手术)。69例手术在当时被视为“根治性”手术。68例患者中有2例(3%)发生吻合口漏,均未进行额外手术即康复。在接受“根治性”手术的69例患者中,有2例(3%)出现局部复发。在中位随访190周时,Dukes分期A、B、C和D期的生存率分别为100%、83%、68%和18%。
在病例组合广泛且年病例数相对较少的外科诊所中,围手术期发病率和局部疾病控制所衡量的结果与大型中心相当。在决定直肠癌手术后的结果时,适当的外科培训和对技术细节的关注可能与病例数同样重要。