Neupert Walter, Brunner Michael
Institut für Physiologische Chemie, Universität München, Butenandtstrabetae 5, Gebäude B, D-81377 Munich, Germany.
Nat Rev Mol Cell Biol. 2002 Aug;3(8):555-65. doi: 10.1038/nrm878.
Proteins that are destined for the matrix of mitochondria are transported into this organelle by two translocases: the TOM complex, which transports proteins across the outer mitochondrial membrane; and the TIM23 complex, which gets them through the inner mitochondrial membrane. Two models have been proposed to explain how this protein-import machinery works -- a targeted Brownian ratchet, in which random motion is translated into vectorial motion, or a 'power stroke', which is exerted by a component of the import machinery. Here, we review the data for and against each model.
destined for the matrix of mitochondria are transported into this organelle by two translocases: the TOM complex, which transports proteins across the outer mitochondrial membrane; and the TIM23 complex, which gets them through the inner mitochondrial membrane. Two models have been proposed to explain how this protein-import machinery works -- a targeted Brownian ratchet, in which random motion is translated into vectorial motion, or a 'power stroke', which is exerted by a component of the import machinery. Here, we review the data for and against each model.
TOM复合体，它负责将蛋白质转运穿过线粒体外膜；以及TIM23复合体，它使蛋白质穿过线粒体内膜。已经提出了两种模型来解释这种蛋白质导入机制是如何工作的——一种是定向布朗棘轮模型，其中随机运动被转化为矢量运动，另一种是“动力冲程”模型，它由导入机制的一个组件施加。在这里，我们回顾了支持和反对每个模型的数据。
