Brockes Jeremy P, Kumar Anoop
Department of Biochemistry & Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.
Nat Rev Mol Cell Biol. 2002 Aug;3(8):566-74. doi: 10.1038/nrm881.
Adult urodele amphibians, such as the newt, can regenerate their limbs and various other structures. This is the result of the plasticity and reprogramming of residual differentiated cells, rather than the existence of a 'reserve-cell' mechanism. The recent demonstrations of plasticity in mouse myotubes should facilitate comparative studies of the pathways that underlie the regenerative response, as well as proposing new approaches to promote mammalian regeneration.
成年有尾两栖动物，如蝾螈，能够再生它们的肢体和各种其他结构。这是残余分化细胞可塑性和重编程的结果，而非“储备细胞”机制的存在。最近在小鼠肌管中发现的可塑性应有助于对再生反应潜在途径进行比较研究，并提出促进哺乳动物再生的新方法。
