Brockes Jeremy P, Kumar Anoop
Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.
Science. 2005 Dec 23;310(5756):1919-23. doi: 10.1126/science.1115200.
The regeneration of complex structures in adult salamanders depends on mechanisms that offer pointers for regenerative medicine. These include the plasticity of differentiated cells and the retention in regenerative cells of local cues such as positional identity. Limb regeneration proceeds by the local formation of a blastema, a growth zone of mesenchymal stem cells on the stump. The blastema can regenerate autonomously as a self-organizing system over variable linear dimensions. Here we consider the prospects for limb regeneration in mammals from this viewpoint.
成年蝾螈复杂结构的再生依赖于可为再生医学提供指导的机制。这些机制包括分化细胞的可塑性以及再生细胞中局部线索（如位置身份）的保留。肢体再生通过残端间充质干细胞生长区——芽基的局部形成来进行。芽基可作为一个自组织系统在可变的线性维度上自主再生。在此，我们从这一观点出发来探讨哺乳动物肢体再生的前景。
