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成年大鼠的实验性蛋白质缺乏

Experimental protein deficiency in adult rats.

作者信息

Campana A O, Burini R C, Outa A Y, De Camargo J L

出版信息

Rev Bras Pesqui Med Biol. 1975 May-Aug;8(3-4):221-6.

PMID:1215575
Abstract

Male adult rats of the Wistar strain were fed "ad libitum" either a protein-free or a 20% casein diet for a period of 28 to 32 days. At the end of the experimental procedure, the animals given the protein-free diet presented a marked loss of body weight plus low levels of plasma protein and albumin concentration. Their livers showed diffuse fatty changes; most of the animals had moderate to severe fatty liver infiltration. They had a negative cumulative nitrogen balance; on the contrary, rats fed the 20% casein diet showed nitrogen retention. The animals of one of the two protein-deficient groups had a significant lower food intake than its control group. However, when food intake was related to animal body weight (g/100 g), the rates of rats on the 20% casein diet and those on protein-free diet were not significantly different.

摘要

将Wistar品系的成年雄性大鼠随意喂食无蛋白饮食或20%酪蛋白饮食,持续28至32天。在实验过程结束时,食用无蛋白饮食的动物出现明显体重减轻,同时血浆蛋白和白蛋白浓度较低。它们的肝脏出现弥漫性脂肪变化;大多数动物有中度至重度脂肪肝浸润。它们有负的累积氮平衡;相反,喂食20%酪蛋白饮食的大鼠表现出氮潴留。两个蛋白质缺乏组中的一组动物的食物摄入量明显低于其对照组。然而,当食物摄入量与动物体重相关时(克/100克),喂食20%酪蛋白饮食的大鼠和无蛋白饮食的大鼠的进食率没有显著差异。

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2
Effect of protein-calorie malnutrition on catecholamine levels and weight of heart in rats.
J Neural Transm. 1980;48(2):85-99. doi: 10.1007/BF01250038.
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Hepatic lesions in protein-deficient adult rats.蛋白质缺乏成年大鼠的肝脏病变
Br J Exp Pathol. 1978 Apr;59(2):158-66.