吗啡、美沙酮和α-1-乙酰美沙酮皮下注射对大鼠的抗伤害感受作用持续时间。
Duration of antinociceptive action of morphine, methadone and alpha-l-acetylmethadol subcutaneously in rats.
作者信息
Wax J, McLean J R, Tessman D K, McCarthy D A, Nuite J A
出版信息
Res Commun Chem Pathol Pharmacol. 1975 Dec;12(4):613-20.
PMID:1215653
Abstract
The duration of antinociceptive action of alpha-l-acetylmethadol (LAM), determined in the rat tail pinch test, was 6 times that of morphine and 3 times that of methadone. Onset of activity was considerably later after LAM than after morphine or methadone.
摘要
在大鼠夹尾试验中测定的α-1-乙酰美沙多（LAM）的抗伤害感受作用持续时间是吗啡的6倍，美沙酮的3倍。LAM作用的起效时间比吗啡或美沙酮晚得多。
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