Bellward G D, Dawson R, Otten M
Res Commun Chem Pathol Pharmacol. 1975 Dec;12(4):669-84.
Adult male rats were exposed to dieldrin-contaminated rations. The hydroxylation of benzpyrene (AHH) and hydration of styrene oxide (EH) by the hepatic microsomal fraction were followed. At dieldrin levels of 5 to 25 ppm for one week, the EH activity increased from 19% to 115% above control levels respectively. Animals exposed to 25 ppm developed elevated EH activities after a few days, with a maximum increase of 2.5 times control levels after two weeks. AHH activity was not elevated over control levels at any dose or time studied. Slight but significant increases in levels of cytochrome P-450 were observed. Pentobartibal sleeping time was decreased to 61% of control levels after exposure to 20 ppm dieldrin-contaminated food for 7 days. Two days of intraperitoneal administration of technical grade dieldrin, analytical grade dieldrin and analytical grade aldrin gave similar increases in EH activity within this group. Again, no changes in AHH activity were seen.
成年雄性大鼠接触了受狄氏剂污染的日粮。对肝微粒体部分中苯并芘的羟化作用（芳烃羟化酶）和环氧苯乙烯的水化作用（环氧化物水化酶）进行了跟踪研究。在狄氏剂含量为5至25 ppm的情况下暴露一周，环氧化物水化酶的活性分别比对照水平提高了19%至115%。接触25 ppm狄氏剂的动物在几天后环氧化物水化酶活性升高，两周后最大增幅为对照水平的2.5倍。在所研究的任何剂量或时间下，芳烃羟化酶的活性均未超过对照水平。观察到细胞色素P - 450水平有轻微但显著的升高。在接触含20 ppm狄氏剂的污染食物7天后，戊巴比妥睡眠时间降至对照水平的61%。在该组内，腹腔注射工业级狄氏剂、分析级狄氏剂和分析级艾氏剂两天，环氧化物水化酶活性有类似的增加。同样，未观察到芳烃羟化酶活性有变化。
