在诱变检测系统中鳟鱼肝脏酶对黄曲霉毒素B1的激活作用以及多氯联苯的抑制作用1。
Trout hepatic enzyme activation of aflatoxin B1 in a mutagen assay system and the inhibitory effect of PCBs1.
作者信息
Stott W T, Sinnhuber R O
出版信息
Bull Environ Contam Toxicol. 1978 Jan;19(1):35-41. doi: 10.1007/BF01685764.
PMID:415776
Abstract
In summary, it was demonstrated that the trout PMF may be successfully employed in the Ames mutagen assay method by utilization of proper salts solution and a metabolic preincubation period at 25 degrees C. It has also been observed that, unlike the rat, pretreatment of rainbow trout with various PCBs decrease the mutagen assay response to AFB.
摘要
总之，研究表明，通过使用合适的盐溶液并在25摄氏度下进行代谢预孵育期，鳟鱼微粒体酶系（PMF）可成功应用于艾姆斯氏诱变试验方法。还观察到，与大鼠不同，用各种多氯联苯预处理虹鳟鱼会降低对黄曲霉毒素B1（AFB）的诱变试验反应。
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