Süess V, Froesch E R
Schweiz Med Wochenschr. 1975 Oct 11;105(41):1315-8.
The loss of insulin due to adsorption to glass and tubing has been quantitatively determined. The properties of albumin, plasma protein, gelatin, heparin and Rheomacrodex in the prevention of insulin adsorption have been tested. The loss of insulin given by intravenous infusion is reproducible and constant for any given situation. The loss of insulin increases as the ratio of volume to glass surface decreases and as the time of contact between insulin and glass is prolonged. There is an almost linear relationship between insulin loss and insulin concentration, as would be expected if insulin binding by glass was an unspecific phenomenon. Albumin and plasma protein almost completely prevent insulin adsorption. In most clinical situations the loss of insulin through adsorption to glass and tubing can be ignored, and hence no albumin or plasma protein needs to be added to the solution.
已对因吸附于玻璃和管道而导致的胰岛素损失进行了定量测定。已测试了白蛋白、血浆蛋白、明胶、肝素和右糖酐铁在预防胰岛素吸附方面的特性。对于任何给定情况，静脉输注胰岛素的损失是可重复且恒定的。随着体积与玻璃表面的比例降低以及胰岛素与玻璃接触时间延长，胰岛素损失增加。正如预期的那样，如果玻璃对胰岛素的结合是一种非特异性现象，那么胰岛素损失与胰岛素浓度之间几乎呈线性关系。白蛋白和血浆蛋白几乎完全可防止胰岛素吸附。在大多数临床情况下，因吸附于玻璃和管道而导致的胰岛素损失可忽略不计，因此无需在溶液中添加白蛋白或血浆蛋白。
