干燥综合征中HL - A8频率增加。

Increased frequency of HL-A8 in Sjogren's syndrome.

作者信息

Gershwin M E, Terasaki I, Graw R, Chused T M

出版信息

Tissue Antigens. 1975 Nov;6(5):342-6. doi: 10.1111/j.1399-0039.1975.tb00653.x.

DOI:10.1111/j.1399-0039.1975.tb00653.x

Abstract

The histocompatibility antigen, HL-A8, was found to be elevated in patients with Sjogren's syndrome. Among 24 patients, the frequency of HL-A8 was 58% compared to 21% among controls (P less than 0.001 after correction). With the addition of this disorder to the list of other autoimmune diseases associated with HL-A8, it now seems possible to postulate a single basis autoimmune defect gene in high linkage disequilibrium with HL-A8.

摘要

发现干燥综合征患者的组织相容性抗原HL - A8水平升高。在24例患者中，HL - A8的出现频率为58%，而对照组为21%（校正后P值小于0.001）。将这种疾病添加到与HL - A8相关的其他自身免疫性疾病列表中后，现在似乎有可能假定存在一个与HL - A8处于高度连锁不平衡状态的单一基础自身免疫缺陷基因。