Teos Leyla Y, Alevizos Ilias
Sjögren's Syndrome and Salivary Gland Dysfunction Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Sjögren's Syndrome and Salivary Gland Dysfunction Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Clin Immunol. 2017 Sep;182:41-47. doi: 10.1016/j.clim.2017.04.018. Epub 2017 May 3.
The pathogenesis of Sjögren's syndrome has not been elucidated. There has been evidence that genetics play an important role in the development of this disease from earlier studies. However, till now only a number of genes have been identified to be associated with SS, and these have only a weak or moderate effect. In this review we summarize the findings of the genetics studies and emphasize the need of large multicenter projects that will increase the sample sizes to provide more meaningful associations, as is the case in other common autoimmune diseases.
干燥综合征的发病机制尚未阐明。早期研究已有证据表明遗传学在该疾病的发展中起重要作用。然而，迄今为止，仅发现一些基因与干燥综合征相关，且这些基因的作用仅为弱或中度。在本综述中，我们总结了遗传学研究的结果，并强调需要开展大型多中心项目，以增加样本量，从而提供更有意义的关联，就像其他常见自身免疫性疾病那样。
