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本文引用的文献

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Sjögren's syndrome (Sicca syndrome): current issues.干燥综合征（口眼干燥综合征）：当前问题
Ann Intern Med. 1980 Feb;92(2 Pt 1):212-26. doi: 10.7326/0003-4819-92-2-212.
2
Antibodies to extractable nuclear antigens in 173 patients with DNA-binding positive SLE: an association between antibodies to ribonucleoprotein and Sm antigens observed by counterimmunoelectrophoresis.173例DNA结合阳性系统性红斑狼疮患者可提取核抗原抗体：对流免疫电泳观察核糖核蛋白抗体与Sm抗原抗体之间的关联
J Clin Lab Immunol. 1982 May;8(1):13-7.
3
Serologic subsets in systemic lupus erythematosus: an examination of autoantibodies in relationship to clinical features of disease and HLA antigens.系统性红斑狼疮的血清学亚群：自身抗体与疾病临床特征及人类白细胞抗原的关系研究
Arthritis Rheum. 1980 Nov;23(11):1268-73. doi: 10.1002/art.1780231107.
4
Interrelationships of HLA-DR, MB, and MT phenotypes, autoantibody expression, and clinical features in systemic lupus erythematosus.系统性红斑狼疮中HLA - DR、MB和MT表型、自身抗体表达及临床特征的相互关系
Arthritis Rheum. 1982 Sep;25(9):1031-40. doi: 10.1002/art.1780250901.
5
HLA-D antigen frequencies in Sjögren's syndrome. Differences between the primary and secondary form.干燥综合征中HLA - D抗原频率。原发性与继发性形式的差异。
Scand J Rheumatol. 1981;10(2):124-8. doi: 10.3109/03009748109095284.
6
Neonatal lupus erythematosus with heart block: family study of a patient with anti-SS-A and SS-B antibodies.新生儿红斑狼疮伴心脏传导阻滞：一例抗SS - A和SS - B抗体阳性患者的家系研究
Arthritis Rheum. 1983 Feb;26(2):210-3. doi: 10.1002/art.1780260215.
7
Sjögren's syndrome. Influence of multiple HLA-D region alloantigens on clinical and serologic expression.干燥综合征。多种HLA - D区域同种异体抗原对临床和血清学表现的影响。
Arthritis Rheum. 1984 Nov;27(11):1245-53. doi: 10.1002/art.1780271106.
8
The distribution of DR5, MT2, and MB3 specificities on human Ia subsets.DR5、MT2和MB3特异性在人Ia亚群上的分布。
Immunogenetics. 1983;17(4):371-86. doi: 10.1007/BF00372456.
9
Molecular relationships of the human B cell alloantigens, MT2, MB3, MT4, and DR5.人类B细胞同种异体抗原MT2、MB3、MT4和DR5的分子关系
J Immunol. 1982 Apr;128(4):1809-18.
10
Systemic lupus erythematosus in the community. Incidence, prevalence, outcome, and first symptoms; the high prevalence in black women.社区中的系统性红斑狼疮。发病率、患病率、转归及首发症状；黑人女性中的高患病率。
Arch Intern Med. 1974 Dec;134(6):1027-35.

意大利原发性干燥综合征患者的人类白细胞抗原

HLA antigens in Italian patients with primary Sjögren's syndrome.

作者信息

Vitali C, Tavoni A, Rizzo G, Neri R, D'Ascanio A, Cristofani R, Bombardieri S

出版信息

Ann Rheum Dis. 1986 May;45(5):412-6. doi: 10.1136/ard.45.5.412.

DOI:10.1136/ard.45.5.412
PMID:3718016
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1001902/
Abstract

Twenty eight Italian patients with primary Sjögren's syndrome were typed for class I and class II alloantigens of the major histocompatibility complex. Patients with Sjögren's syndrome had higher prevalence of DR3 (46.4% v 14% in the control population, p corrected less than 0.02), while similar prevalence was found for DR2 and DRw52 alloantigens. DR3 correlated with DRw52 (p less than 0.0001), anti-Ro(SSA) (p less than 0.0002) and anti-La(SSB) (p less than 0.02) antibodies, and extraglandular manifestations (p less than 0.02). In addition, extraglandular involvement was associated with anti-Ro antibodies (p less than 0.05) and raised gammaglobulins (p less than 0.02). In Italian patients with primary Sjögren's syndrome DR3 is the genetic marker related to this clinical entity and seems to identify a disease subset characterised by autoantibody production and extraglandular manifestations.

摘要

对28例原发性干燥综合征意大利患者进行了主要组织相容性复合体I类和II类同种异体抗原分型。干燥综合征患者中DR3的患病率较高（46.4%，而对照人群中为14%，校正后p<0.02），而DR2和DRw52同种异体抗原的患病率相似。DR3与DRw52（p<0.0001）、抗Ro(SSA)（p<0.0002）和抗La(SSB)（p<0.02）抗体以及腺体外表现相关（p<0.02）。此外，腺体外受累与抗Ro抗体（p<0.05）和γ球蛋白升高（p<0.02）有关。在意大利原发性干燥综合征患者中，DR3是与该临床实体相关的遗传标记，似乎可识别一个以自身抗体产生和腺体外表现为特征的疾病亚组。