意大利原发性干燥综合征患者的人类白细胞抗原
HLA antigens in Italian patients with primary Sjögren's syndrome.
作者信息
Vitali C, Tavoni A, Rizzo G, Neri R, D'Ascanio A, Cristofani R, Bombardieri S
出版信息
Ann Rheum Dis. 1986 May;45(5):412-6. doi: 10.1136/ard.45.5.412.
Twenty eight Italian patients with primary Sjögren's syndrome were typed for class I and class II alloantigens of the major histocompatibility complex. Patients with Sjögren's syndrome had higher prevalence of DR3 (46.4% v 14% in the control population, p corrected less than 0.02), while similar prevalence was found for DR2 and DRw52 alloantigens. DR3 correlated with DRw52 (p less than 0.0001), anti-Ro(SSA) (p less than 0.0002) and anti-La(SSB) (p less than 0.02) antibodies, and extraglandular manifestations (p less than 0.02). In addition, extraglandular involvement was associated with anti-Ro antibodies (p less than 0.05) and raised gammaglobulins (p less than 0.02). In Italian patients with primary Sjögren's syndrome DR3 is the genetic marker related to this clinical entity and seems to identify a disease subset characterised by autoantibody production and extraglandular manifestations.
对28例原发性干燥综合征意大利患者进行了主要组织相容性复合体I类和II类同种异体抗原分型。干燥综合征患者中DR3的患病率较高（46.4%，而对照人群中为14%，校正后p<0.02），而DR2和DRw52同种异体抗原的患病率相似。DR3与DRw52（p<0.0001）、抗Ro(SSA)（p<0.0002）和抗La(SSB)（p<0.02）抗体以及腺体外表现相关（p<0.02）。此外，腺体外受累与抗Ro抗体（p<0.05）和γ球蛋白升高（p<0.02）有关。在意大利原发性干燥综合征患者中，DR3是与该临床实体相关的遗传标记，似乎可识别一个以自身抗体产生和腺体外表现为特征的疾病亚组。
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