他汀类药物事件试验的临床意义。

Clinical implications of statin event trials.

作者信息

Goldberg Anne Carol

机构信息

Lipid Research Center, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8046, St. Louis, MO 63110, USA.

出版信息

Curr Atheroscler Rep. 2002 Sep;4(5):337-42. doi: 10.1007/s11883-002-0070-y.

DOI:10.1007/s11883-002-0070-y

PMID:12162932

Abstract

Event trials using statin therapy have shown a beneficial effect on rates of cardiovascular events. The three statins that have been used in long-term trials have shown generally similar effects on rates of myocardial infarction, stroke, revascularizations, and mortality. Safety data appear to be comparable for lovastatin, pravastatin, and simvastatin. Long-term trials of other statins are in progress or pending. The question of how much low-density lipoprotein cholesterol should be lowered may be answered by studies currently in progress.

摘要

使用他汀类药物治疗的事件试验已显示出对心血管事件发生率有有益影响。在长期试验中使用的三种他汀类药物对心肌梗死、中风、血管重建和死亡率的发生率总体上显示出相似的效果。洛伐他汀、普伐他汀和辛伐他汀的安全性数据似乎具有可比性。其他他汀类药物的长期试验正在进行或有待开展。目前正在进行的研究可能会回答低密度脂蛋白胆固醇应降低多少的问题。